On 12 June 1972, a McDonnell Douglas DC-10, just a few months old, operating as American Airlines Flight 96 from Detroit, Michigan, to Buffalo, New York, suffers an explosive decompression after a cargo door in the lower rear fuselage bursts open. The crew makes an emergency landing at Detroit without any loss of life. Two years later, on 3 March 1974, Turkish Airlines Flight 981 suffers a similar sequence of events during a flight from Paris to London. This time, the DC-10's hydraulic systems are damaged enough that the crew loses control, and the aircraft crashes in a forest near Senlis outside Paris, killing all 346 on board. At the time, it was the worst aviation disaster in history. A design fault with the cargo door mechanism was not rectified after the first accident, and the second DC-10's door opened during flight, causing the crash.

Find out what went wrong when a Kazakhstan Airlines jet and a Saudi Airways plane collided in the worst mid-air crash in aviation history, killing 349 people on November 12, 1996.

On 22 August 1985, an engine of British Airtours Flight 28M fails during takeoff, puncturing a hole in the wing fuel tank and starting a fire. The crew successfully abandons the takeoff and stops the aircraft on the runway, but the fire spreads to the cabin. 55 people die before they can evacuate, mainly due to inhaling toxic smoke. The investigation found that fatigue of a part in the engine caused it to fail.

On 26 June 1988, Air France Flight 296 fails to climb and crashes into trees after performing a flyby during an airshow at Mulhouse-Habsheim Airport, killing three people. The cause of this crash remains in dispute.

On 25 February 2009, Turkish Airlines Flight 1951 is on approach to land at Schiphol in Amsterdam, when it stalls and crashes 1.5 kilometres from the runway. Nine people, including the three cockpit crew members, are killed. A faulty radar altimeter caused the aircraft's flight control computer to automatically reduce engine thrust prematurely, and the flight crew failed to notice the resulting drop in airspeed until it was too late.

On 12 February 2009, Colgan Air Flight 3407 stalls at low altitude and dives into a residential area near Buffalo, New York. All on board and one person on the ground are killed. Several critical errors made by the flight crew might have been the result of their fatigue.

On 12 December 1985, Arrow Air Flight 1285, carrying troops of the US Army's 101st Airborne Division, stalls and crashes just seconds after taking off from Gander International Airport in Canada, killing all 256 people on board. The cause of the crash remains disputed.

On 6 February 1958, British European Airways Flight 609, carrying members of the famed Manchester United association football team, club officials and journalists, crashes into a house about 300 meters from the end of the runway in Munich after it fails to become airborne, killing 23 of the 44 people on board. The cause of the crash was slush on the runway, which slowed the aircraft down and prevented it from reaching takeoff speed.

On 8 October 2001, Scandinavian Airlines Flight 686, carrying 110 people bound for Copenhagen, Denmark, is taking off at Milan's Linate Airport in thick fog. On the runway, it collides with an Air Evex business jet carrying four people bound for Paris, France. The airliner suffers major damage and crashes into a building shortly afterwards. All 114 people on board the two aircraft are killed, along with four on the ground. The crew of the business jet had made a wrong turn while taxiing in the fog and inadvertently taxied onto the runway.

On 25 May 1979, the left engine of American Airlines Flight 191 falls off moments after takeoff at Chicago's O'Hare International Airport. The aircraft crashes into an open field shortly thereafter, killing all 271 people on board and two people on the ground. The engine fell off because the pylon attaching it to the wing had suffered damage caused by improper maintenance procedures.