Jess LaCroix and his elite team of FBI Fugitive Task Force agents track a doctor who's deeply involved in a world of organized crime, drugs and lies, and is on the run after a phone call records him delivering his wife's fatal shot.

Barnes goes on a dangerous undercover mission involving an ambitious gang leader who is plotting turf wars and massacres across the Bronx in a bid for more power.

After taking down a terrorist, the FBI and their Fugitive Task Force partners turn their attention to the terrorist’s wife who escaped with one million dollars and is determined to follow through with her husband’s deadly plan. Also, LaCroix’s daughter, Tali, is taken away by ICE, but as Jess tracks her down, he realizes her detainment may be more than just random coincidence.

The crossover starts on FBI S02E18 American Dreams (I).

After witnessing her husband's murder, a woman is kidnapped from her home along with a mysterious stash of money hidden in her floor. When Jess realizes there may be a connection to one of his past cases, the need to find the kidnapper becomes personal.

When a young man accidentally shoots a cop in self-defense and goes on the run, the team members find themselves in a moral dilemma on the best way to carry out justice. Also, Barnes and her wife struggle with their plans to have another child.

A local FBI case involving two murdered women and a sea of powerful men turns into a manhunt for the dangerous leader of a far-reaching criminal enterprise.

The crossover starts on FBI S04E01 All That Glitters (I). It continues on FBI: International S01E01 Pilot (III).

The team investigates the murder of a professional basketball player’s wife, who was a famous lifestyle guru. Also, Kristin and her ex-husband grow closer, and Special Agent in Charge Isobel Castille checks in with the team on the high-profile case.

The team must track down a murderous member of the incel community targeting those he believes never give him a chance. Also, Barnes, Hana, Ortiz and Kristin deal with their grief in the wake of Jess’ death.

The team gets called to Vermont after a married couple who grow illegal marijuana massacres their employees. Also, Barnes begins to regret not taking any time off to bond with her new baby.

As the team chases after the suspects behind an explosion at an Ohio energy plant, they are led towards a major crypto company with enemies looking to take it down; Remy and his sister close a chapter in their lives.

The clock ticks as the FBI and FBI: Most Wanted teams join forces to hunt down the fugitive terrorists as they get closer to carrying out a plot to destroy a major New York City landmark and cause devastating civilian casualties.

The crossover starts on FBI: International S02E16 Imminent Threat (I) and FBI S05E17 Imminent Threat (II).

The team helps Remy try to catch his brother’s real killer 25 years after Mikey was murdered.

The Fugitive Task Force is called in to hunt down a missing teen from New Jersey who has a connection to a classmate's recent suicide. Meanwhile, Cora feels Ray and his father are putting too much pressure on Caleb.

A couple known for their home renovation TV show is thrown into the limelight after the wife is found dead and her husband goes on the run. Meanwhile, Barnes reevaluates her life in New York.

After three men impersonating ICE officers raid a church in New Jersey, the Fugitive Task Force must earn the trust of the reverend to help find the men who were kidnapped. Meanwhile, Remy confronts his own future after learning that Barnes is considering taking a new job.