After taking down a terrorist, the FBI and their Fugitive Task Force partners turn their attention to the terrorist’s wife who escaped with one million dollars and is determined to follow through with her husband’s deadly plan. Also, LaCroix’s daughter, Tali, is taken away by ICE, but as Jess tracks her down, he realizes her detainment may be more than just random coincidence.

The crossover starts on FBI S02E18 American Dreams (I).

With COVID-19 devastating the country, two gunmen take out their desperation and rage on the elite class they perceive to be oppressing them; Jess' father returns and may not be over his old ways.

When a hacker triggers a car crash that kills a family of three, the team races to hunt him down as his ransomware demands escalate and his final target becomes apparent.

The team searches for a young woman who is heading down a deadly path of vengeance, using ties to an online radical conspiracy organization to further her cause. Also, Barnes must make a life-changing decision, finding it hard to not let the dark side of her job affect her.

After a robbery gone wrong ends with a murder and kidnapping, the team races to rescue a mother and daughter whose abductors are not what they seem. Also, Crosby enters a new living arrangement.

The team welcomes a new member as they begin their hunt for a repeat offender and the child he kidnapped after murdering the boy’s single mother. Also, Jess tries to move past the awkward exchange he had with Sarah during their last encounter.

After Crosby's old army buddy is attacked in an apparent drug deal gone wrong, the team's quest for answers uncovers a dangerous web of conspiracy. Also, Jess questions his relationship with Sarah after an unexpected encounter.

When a young man accidentally shoots a cop in self-defense and goes on the run, the team members find themselves in a moral dilemma on the best way to carry out justice. Also, Barnes and her wife struggle with their plans to have another child.

The team heads to D.C. to protect Ortiz's former informant after a hitman tries to kill her. Also, Sarah helps Jess' family prepares for Byron and Marie's last-minute wedding on Jess' farm.

Jess and the Most Wanted team head to Tennessee to track down an undercover DEA agent who appears to have turned dirty amid a major drug ring operation. Also, Sarah wonders if it was a mistake to move in with Jess and Tali so soon.

A local FBI case involving two murdered women and a sea of powerful men turns into a manhunt for the dangerous leader of a far-reaching criminal enterprise.

The crossover starts on FBI S04E01 All That Glitters (I). It continues on FBI: International S01E01 Pilot (III).

The team must determine if the kidnapping of a young Chinese-American woman is a random hate crime or if she was specifically targeted, in order to find her. Also, Jess and Sarah struggle with Tali’s continued rebellious streak.

The team attempts to hunt down a family annihilator before he continues his murder spree. Also, Barnes’ intrusive mother puts pressure on her marriage.

After a prized Kentucky racehorse is stolen and its groomer is taken hostage, the team quickly learns they may be the only ones who consider the young woman’s safety a priority over the horse’s. Also, Byron returns to celebrate the holidays with Jess and his family.

The team hunts for a young man who is using napalm-style bombs to attack his targets. Also, with Tali away, Jess and Sarah begin to adjust to their empty nest.

The team pursues an abusive man on the war path to find his ex-girlfriend, who is trying to escape him for good. Also, Jess and Sarah make plans to take their dream vacation together.

The team gets called to Vermont after a married couple who grow illegal marijuana massacres their employees. Also, Barnes begins to regret not taking any time off to bond with her new baby.

Remy and the team investigate the homicides of two Army veterans in a murder spree connected to their time in Afghanistan.

The team searches for a murderer recreating the chilling killings of a notorious ‘80s mobster.

The team chases an oligarch who goes on a terror spree in New York City in a desperate attempt to escape his impossible situation.

When the woman whose visage is the face of a popular AI bot is found violently murdered inside a Brooklyn hotel room, the Fugitive Task Force jumps into action to find out who lured her there in the first place.

The Fugitive Task Force races to catch the culprit threatening Manhattan with a dirty bomb. Meanwhile, Ray prepares to celebrate a major life milestone as his wedding to Cora approaches.

When a detective is brutally murdered, the Fugitive Task Force investigates a string of gruesome killings. Meanwhile, Remy and Abby's relationship grows stronger.

After a simple act of defiance by a couple of young climate activists goes south, the Fugitive Task Force works to hunt them down before their plans take a devastating turn. Meanwhile, Nina and Scola face family drama when they host her father and sister after they come to town.

When a privately owned security corporation warehouse is robbed, the Fugitive Task Force is called in for assistance as the sophisticated team of thieves plan their next heist. Meanwhile, Ray and Cora wrestle with Caleb’s sudden desire to spend time with his biological father.

After a Queens district attorney and her husband are executed, the Fugitive Task Force uncovers a money laundering scheme connecting a violent biker gang to Wall Street. Meanwhile, Remy decides to take his relationship with Abby to a new level after he reconnects with an old friend.

The Fugitive Task Force investigates a series of deadly fires involving the descendants of those who caused the infamous 1985 MOVE bombing in Philadelphia. Meanwhile, Nina's sister turns to her in a time of need.

The Fugitive Task Force is sent on a hunt in Philadelphia to investigate a double homicide and the abduction of a 14-year-old girl in the foster care system. Meanwhile, Ray’s father is hospitalized after an accident while helping out around the house.

A string of late-night murders with the same M.O. sends the Fugitive Task Force on a hunt for a serial killer with ties to a radical feminist group. Meanwhile, Nina's sister asks her for a big favor, causing a strain on Scola and Nina's relationship.

The Fugitive Task Force is thrown into the world of the wealthy and twisted after a Rhode Island socialite is murdered in her own mansion. Meanwhile, Barnes contemplates big changes.

After three men impersonating ICE officers raid a church in New Jersey, the Fugitive Task Force must earn the trust of the reverend to help find the men who were kidnapped. Meanwhile, Remy confronts his own future after learning that Barnes is considering taking a new job.