Clark and Chrissy both notice a small crack in Lois' game face. Sarah and Jordan have an awkward encounter, and Lana receives a panicked phone call.

Clark and General Lane are both having a hard time giving Lois room to make her own decisions. Meanwhile, Lana and Sarah have a run-in with an old friend at the diner.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis.

After learning about Bruno and Peia, Clark works to reignite Lois' interest in taking Bruno down; elsewhere, Natalie meets Matteo's parents, with disastrous consequences.

Superman and John Henry clash over how to handle Bruno Mannheim, while Lois worries over upcoming treatments and confides in Lana about her early courtship with Clark.

Lois attempts to interview Peia in the hopes of unearthing the truth about an old case, while Clark struggles to spend quality time with the boys.

Clark helps Lois prepare for a procedure but must leave the boys with her to help John Henry and General Lane track down the Mannheims.