Van der Valk and his team return to investigate new crimes in Amsterdam. In addition to solving murder cases, Van der Valk has to deal with an unwelcome past romance resurfacing as well as find a way to make one of his beloved team members confront their own mortality.

Van der Valk and the team are called in when a scientist researching a potential breakthrough in the treatment of cancer is found dead. Van der Valk's ex-flame Kalie Tenkers returns to help the team investigate why he was killed and if there is a link to pharmaceutical billionaire Freddie Klink.