After Franklin’s sudden polio diagnosis, Eleanor Roosevelt commits to enabling his political future despite pressure from her mother-in-law, Sara. As the Watergate scandal unfolds, Betty Ford unexpectedly becomes Second Lady upon Jerry’s nomination as Vice President and she clashes with his staff over her newly public role. Following the historic 2008 election, Michelle Obama wrestles with the expectations and dangers that Barack and their children face as the first Black family to live in the White House.

Moved by the toll the Great Depression has taken on the country, Eleanor presses Franklin to act more boldly and lobbies for an unprecedented formal position in the administration while helping craft his inaugural address. After Nixon’s resignation, Jerry assumes the presidency and Betty becomes First Lady days before an important state dinner, which Jerry's staff try to cancel. In the days leading up to Barack’s inauguration, Michelle faces opposition from members of his transition team who plan to diminish her role.