When Bashir Hamed finds himself at the site of a tragic accident, his medical training takes over as he works to save the wounded. At York Memorial Hospital, the staff treat patients from the accident while concerns arise about their Chief of Emergency Medicine, Dr. Jed Bishop.

When Bash and Mags work together to treat a patient with a tricky diagnosis, Mags realizes that Bash’s experience as a doctor in Syria has led to an instinct-based approach. Head nurse Claire Malone is concerned that Dr. Bishop is already working following his accident. June struggles to put her foot down with Dr. Singh concerning the needs of a patient, and Theo works to build a connection with Bash.

Bash is divided between his work at the hospital and a patient he is helping to treat remotely in Syria. Dr. Bishop puts extra pressure on Bash, while Theo feels powerless when something happens to one of his daughters back home. Meanwhile, a patient puts Mags’ moral convictions to the test, and June tries to improve her social skills.

Bash and Amira settle into a new environment, while at the hospital Bash helps a worried couple expecting their first child. Dr. Bishop puts Mags to the test by personally evaluating her performance in the emergency department. Meanwhile, Theo is surprised by his reaction in the face of an altercation, and Attending Dr. Wendy Atwater gives June an interesting case.

Bash provides medical care to a friend who is reluctant about treatment, while Mags has her hands full with a young woman who seems to be withholding information. Dr. Bishop offers Mags an incredible opportunity, and someone from June’s past tries to reach out to her. Faced with a young athlete without a clear diagnosis, Theo also has to navigate the patient’s complicated family dynamic.

When an explosion takes place near the hospital, Bash runs toward the danger. Mags treats a patient without all the information she needs, and June struggles to take initiative. When a schoolgirl is brought into the hospital in cardiac arrest, Theo does everything he can to save her. Through all the chaos, Claire takes the time to help a teenage girl in need.

When a young mother addicted to opioids nearly dies, Bash must figure out whether she's using again, or if something else is causing her deadly symptoms. Mags tries to help a patient who isn't healing properly, while June is blindsided by her father.

Bash and Mags race to save a woman with mysterious symptoms who was nearly killed by their team's medical error. Theo tries to help a gravely ill teen and his family deal with the possibility that medical hope has run out.

A bus full of kids crashes and sends the team racing. Bash’s life is upended when he is reunited with a woman from his past. With Dr. Bishop still unconscious after his stroke, Mags struggles to find support in her mentor’s absence. Theo faces repercussions from his family after taking a full-time job away from home, and June has an important career decision to make.

Rania's arrival triggers unwanted memories for Bash; Mags can't win her new boss' approval.

A morbidity and mortality review forces Bash and Dr. Bishop into conflict.

As Dr. Bishop faces challenges returning to work, Bash's loyalty is tested; Mags has a harrowing encounter with an aggressive patient.

Pressured by a patient's father, Bash must make an impossible choice to save a life.

With his future as a doctor on the line, Bash must suppress his instincts and avoid any chance of risk.

Bash draws on his war zone experience when harsh weather causes the hospital to lose power.

As shakeups force major turmoil at the hospital, Bash and Amira take a trip.

Bash saves a hostile man during his commute and gets some shocking news about his future.

As Bash fights for Dr. Bishop's legacy, big questions about his own future are finally answered.

Bash's decisions lead to conflict with the new chief of emergency medicine; Mags struggles to save a patient who thinks the system gave up on her; June has trouble with her new roommate, and gets a work proposal from Novak; Theo has trouble adapting.

Bash treats a woman whose ketamine therapy goes awry; Mags loses confidence in her new boss; June realizes she has too much on her plate; Theo reunites with a young former patient whose life may depend on the death of another patient.

Bash and Amira have an argument over her future; Bash treats a diabetic woman who is overly dependent on her 18-year-old son; Mags questions herself as she adjusts to very limited parameters.

Bash reels from Amira's bold decision; tensions flare at an after-work dinner party; Devi struggles to keep her staff in line as turmoil erupts over her leadership; Mags treats a highly sensitive person; Theo considers breaking some hospital rules.

Bash's psychiatrist suggests an unexpected form of therapy. Mags gets evicted and meets an old patient who holds a grudge. Theo makes some questionable choices with a patient's mother. June's personal and professional worlds collide.

Bash has a major realization; Mags faces an overwhelming health crisis; Devi stands behind her choices; June confronts loss; Theo witnesses a devastating event.

Bash and Mags team up to save a John and Jane Doe found in the woods. A fully qualified surgeon now, June sees her old mentor in a new light. Suspended from the hospital, Theo longs for the action while treating patients virtually. Devi makes a budget cut decision, which will have major consequences for the Emergency Department.

Bash and Mags fall into friendly competition at work, and a man with superhero ideation crash lands into the Emergency Department. June tries group therapy, and Theo faces a tribunal to decide his fate.

Bash passes on an opportunity, and works cases where things are not as they appear. Mags returns to York Memorial. June navigates loss professionally and personally. Theo goes out on a limb again for a patient. Claire is confronted by Devi and her colleagues about recent challenges.

Bash treats a man injured in a car accident who was saved by the woman who hit him. Devi decides to fight to hold on to the department. In a moment where it is most needed, a former member of the York Memorial team returns.

June and Novak have it out. Theo risks his life for a patient and makes a big decision. Bash rises to the occasion during an emergency and sees how far he's come.