The Shiunji family with their seven children reside in a mansion within Tokyo’s Setagaya ward. The eldest son, Arata, is tired of being pushed around by his five sisters and daydreams of a life without them. That is, until Arata’s father reveals a shocking truth—Arata isn’t biologically related to his sisters! The siblings’ relationships will be tested as they navigate life in this new light.

Even though Seo Dong Hee comes from a poor family background, she has a bright and positive personality. She dreams of becoming a designer and slowly works her way to achieve her dream. She decides to become the mother of her nephew and raise him by herself. She also gets involved with Kang Cha Yeol. Kang Cha Yeol’s father runs a big company. His father wants him to work for his company, but Kang Cha Yeol doesn't want to. He wants to go back to the U.S., but he realizes he can't do anything without his father's financial support. His father tells Kang Cha Yeol to work for 1 year at his company.

Orphaned at young age, abandoned by his uncle and later by his adoptive parents, Sang-doo’s life has been a succession of difficulties. At 27, he makes a living by seducing older women in order to support his daughter’s hospital fee. However, the love he has for his first love, Chae Eun-hwan, keeps him happy and optimistic. When he runs into Eun-hwan again, he decides to give another chance at his love and goes back to high school to be Eun-hwan’s student.

Santino, played by Zaijian Jaranilla, is an orphan boy who became a ward of the local parish church shortly after he was born and was thus raised by priests. Longing for the love of his biological mother, he crosses paths with Jesus whom he affectionately nicknamed "Bro". Upon being granted healing powers, Santino sets out to aid those surrounding him in his home town, from folks with illness, to hardened criminals and disillusioned men who bitterly left their faith.