When Dr. Frankenstein is killed by a monster he created, his daughter and his lab assistant continue his experiments.

Once again tampering with mother nature to disastrous results, Dr. Herbert West continues his research while serving time in a maximum security prison for his previous exploits. West's limited prison-cell experiments are suddenly interrupted by the arrival of a new prison doctor and the brother of the girl who suffered from West's experiments 13 years earlier.

Dr. Frankenstein is left for dead in the woods. His daughter, Dr. Vera Frankenstein, hunts for his attacker: Dr. Cagliostro, a mad scientist who’s created a race of human-animal hybrids.

Features interviews with the cast and crew of Re-Animator (1985), except for the late David Gale.

The six-decade transformation of a block of houses, shown by means of artfully featured archival shots, highlights the beauty and sadness of human-made decay. In the blink of an eye 66 years pass by and a savings bank replaces a church.