Meet Spot, a clever little dog with big dreams of becoming a real boy. When Spot finds out that a crazy scientist can make his wish come true, he takes a cross-country trek with Leonard, his best friend and master, and their mom. However, Dr. Krank's experiments are a little less than perfect, and it will take Leonard and his pet pals to right this genetic wrong.

He has shared our lives for 20,000 years. Along the way, he has helped us find food, kept our livestock, protected us from our enemies, guided us in extreme conditions, and saved us from peril. Now, he comforts us, relieving loneliness and helping us cope with old age. How did dogs come about?