The Dematerialization Phenomenon, in which the real world becomes digital, has become a problem and must be resolved immediately. After hearing of this incident, Netto and Rockman left off after their father and Network Researcher, Yuuichirou. He also had found news of an invasion in the computer of the Trinity Brain trust company: 'The Earth itself will understand the way things stand in the cyber world'. In order to destroy the program causing the incident, Netto and Rockman have to go deep underground. But old enemies await them there, as well as new ones. As they fought each other, the vicious cyber-life, Nebula Grey, awakens. The Dematerialization Phenomenon will not be stopped unless Nebula Grey is defeated.

The year is 21XX. Reploids are commonplace now, after Dr. Cain rediscovered Dr. Light's old lab and based several designs off of Dr. Light's original, called "Mega Man X". X, meanwhile, has joined the Maverick Hunters, and works with unit leader Zero under the command of Commander Sigma. It is their job to terminate reploids who have become violent.

In a prequel to Mega Man Maverick Hunter X, the Maverick Hunters led by X and Zero, under the command of Sigma, face reploids who have become violent.

The live-action adaptation of the well-known video game.