To mark his recent appointment, the new Pope prepares for a tour of Latin America, only to find that the Vatican is bankrupt. A rich Mexican woman offers to help out. In return for financing his trip, she demands he attends an event in his honour in the city of Ciudad Juarez – Mexico’s capital of crime. The “guardian angel” turns out to be a drug trafficker, and when she discovers that a lookalike Pope has been sent in his place, confusion, laughter and unexpected chaos ensue.

Au dernier jour d’un voyage historique au Mexique, le pape est enlevé par un cartel de drogue. Le Saint-Père découvre la personnalité mystique de la cheffe du cartel et les multiples activités de son gang. Mais bientôt la redoutable criminelle découvre qu’elle a enlevé un imposteur.