高中老師恩妤（嚴正嵐 飾）受暗戀對象岳融（涂善存 飾）所邀，意外出席多年未見的大學同學訂婚派對，眾人起鬨挑戰禁忌招鬼遊戲「鬼牽手」，原本以為只是無傷大雅的飯後娛樂，同學卻接連意外死亡，驚恐發現一旦開始這場遊戲，就必須以「牽手」做為交棒儀式，將詛咒持續轉嫁給下一個人，開始牽手之後，就無法停止，詛咒將永遠追隨至死為止…！

High school teacher En-Yu (played by Vera Yen) is invited by her longtime crush, Yue-Rong (played by Charles Tu), to attend a college friend’s engagement party. The gathering takes an unexpected turn when the group decides to play the forbidden supernatural game, *Hold My Hand*. What starts as a seemingly harmless after-dinner pastime soon turns deadly, as friends begin dying one after another. To their horror, they discover that once the game starts, it must be continued through a ritual of hand-holding, passing the curse onto the next person. Once someone clasps hands in the game, they cannot stop—the curse will follow them to the grave…