Desmond Ng started singing professionally in 2009 and achieved Top 8 in a Taiwan singing and songwriting competition in 2010. With his humble personality and fantastic vocals, he won a strong fan base. Desmond took part in "The Getai Challenge" organized by Mediacorp in 2015. His heart-thumping performances during each stage of the competition not only thrilled the audience but also won him the Championship, beating the rest of the contestants including established Getai industry veterans.

In 2016, Desmond began his acting career and acted in 3 dramas. He also ventured in hosting and co-hosted Channel 8’s variety programme “BENGpire”. He was nominated for Best Host and won the Top 10 Most Popular Male Artiste award at Star Awards 2017. Desmond also had the opportunity to act in a local movie, Ah Boys to Men1, directed by Jack Neo.

Desmond sang many popular television theme songs and this includes 《以刚克刚》which won the Best Theme song at Star Awards 2018.

Desmond held his first music showcase with his band AL4HA on 11 November 2018, drawing a fantastic turnout which included fans, media and celebrities. The band was invited to take the stage at the Esplanade Outdoor Theatre for Huayi –Chinese Festival of Arts in February 2019. He represented Singapore in the competition organized by Voice of Vietnam in July 2019 and achieved the Most Potential Award at ASEAN+3 Song Contest 2019 held in Vietnam