Greg Sestero was born and raised in the San Francisco Bay Area. With European parental influence, Greg speaks both French and English. He traveled extensively early on, and holds dual citizenship between France and the United States.

At 17 years old, Greg signed with a prominent San Francisco talent agency. The same year, he left for Milan and Paris to work for designers such as Giorgio Armani and Gian Franco Ferre. Greg returned focused on acting. He began studies at the American Conservatory Theatre in San Francisco. He landed his first role at age 18, on the CBS hit show Nash Bridges (1996). This followed with a role in the Golden Globe nominated film, Patch Adams (1998) starring fellow San Francisco native, Robin Williams. Soon thereafter, Greg was signed by well-known Hollywood agent, Iris Burton, which prompted his move to Los Angeles.

Sestero starred in the notorious The Room (2003), which gained an international cult following as the best worst movie ever made.

in 2013, Sestero wrote a book entitled The Disaster Artist, chronicling his experience making the film and working with its enigmatic director Tommy Wiseau. The book went on to become a critically acclaimed bestseller. In February 2014, the book was optioned to made into a feature film by Hollywood superstars James Franco and Seth Rogen.

Greg Sestero 在旧金山湾区出生和长大。受欧洲父母的影响，格雷格会说法语和英语。他很早就广泛旅行，并拥有法国和美国之间的双重国籍。

17岁时，格雷格与旧金山一家著名的人才经纪公司签约。同年，他前往米兰和巴黎，为乔治·阿玛尼（Giorgio Armani）和吉安·佛朗哥·费雷（Gian Franco Ferre）等设计师工作。格雷格回来了，专注于表演。他开始在旧金山的美国音乐学院剧院学习。他在 18 岁时在 CBS 热门节目 Nash Bridges （1996） 中获得了他的第一个角色。随后，他在金球奖提名电影《补丁亚当斯》（1998）中扮演了一个角色，该片由旧金山本地人罗宾·威廉姆斯主演。此后不久，格雷格被好莱坞著名经纪人艾里斯·伯顿（Iris Burton）签下，这促使他搬到了洛杉矶。

塞斯特罗出演了臭名昭著的《房间》（2003 年），该片作为有史以来最好的最差电影获得了国际狂热的追随者。

2013年，塞斯特罗写了一本名为《灾难艺术家》的书，记录了他制作这部电影的经历，并与神秘的导演汤米·怀索（Tommy Wiseau）合作。这本书后来成为广受好评的畅销书。2014年2月，这本书被好莱坞巨星詹姆斯·弗兰科（James Franco）和塞斯·罗根（Seth Rogen）拍成故事片。