王若君是名资深的护士长，在一次的偶遇中，不顾自身安危，救了惨遭歹徒毒打的刘佑乐，让佑乐对若君感恩不已。 在住院期间，佑乐获得若君的鼓励和细心照顾，决定改变自己的人生，投身成为一名护士。 　　与此同时，原本是软件工程师的傅家梓，也在同时候，搭友人的顺风车，发生车祸。友人Ken在车祸中身受重伤，由于家梓不懂急救，以致Ken最后失血过多身亡。 家梓内疚不已，过后决定转换跑道，报读护理课程，转当护士。这个决定让母亲周好韵大为反对，幸亏获得父亲傅国华的支持。 　　家梓有个弟弟家任，成绩优异，服完兵役后不想即刻继续升学，一心想要寻找人生理想的工作，绕了一大圈，最后发现了工作最大的意义，不在于外在条件，而是可以帮助到人，也让自己成长，和哥哥一样，加入护士行列。 　　若君的姐姐若恩也是一名护士长，性格刚烈，好打不平，对下属又非常严厉，要求很高，又很挑剔，所以人缘不是很好，屡遭病...

This story follows the life of a group of nurses as they take on their challenging routines with professionalism and pride. Wang Ruojun is an experienced nurse who saved Liu You Le from an accident. You Le is grateful towards Ruojun and this incident inspires her to be a nurse. Though successful in her career, Ruojun faced marital woes. Her husband of many years cheated on her and even has a love child outside. Fu Jiazi is originally a software engineer; he lost a friend during a car accident and blames himself for not being able to save his friend. This incident makes him decide to quit his job as a software engineer and become a nurse. Guan Xinni suspects that Xie Yaozong is the man who molested her when she was a child. Because of this misunderstanding, she puts herself in many funny and embarrassing situations. The nurses not only face challenges in their job but also in love as well. Will they be able to resolve their problems in love, career and family?