Who Do You Trust? is an American game show which aired from September 30, 1957, to November 15, 1957, at 4:30 pm, Eastern on ABC, and from November 18, 1957, to December 27, 1963 at 3:30 pm, Eastern - which helped garner a significant number of young viewers coming home from school.

The series was originally emceed by Johnny Carson and originally announced by Bill Nimmo. A year into the run, Nimmo was replaced by Ed McMahon, and from that point until 1992 the two would spend the majority of their careers together. Carson and McMahon departed in 1962 when Carson was hired to take over Tonight Starring Jack Paar on NBC, where Carson would spend the next thirty years, and Woody Woodbury took over the hosting position while Nimmo returned to announce.

While the format was somewhat similar to The Newlywed Game, it was actually much closer to the hit Groucho Marx game You Bet Your Life on NBC.