清源堂名医谷风之子意外溺水身亡，谷老太归咎于管家房成。房成心中不快，恰逢他与有夫之妇何秀所生女儿蔷薇无处寄养，故将谷风寄养在外的女儿忍冬与其掉包。蔷薇被带回谷家，成了掌上明珠，而忍冬则被送到何秀处，在贫寒困苦中长大。忍冬机缘巧合下来到清源堂工作，与同样命运多舛的韩冲相识。她乐观的天性和医学天赋，很快赢得了众人的喜爱，甚至蔷薇暗恋多年的正定，也对忍冬渐生好感。房成得知忍冬身份后，陷害忍冬，谷老太因此对忍冬处处刁难。蔷薇获悉真相后，为保住自己地位，也不惜一切代价力图阻止忍冬重回谷家。在韩冲和正定的帮助下，忍冬凭借自己不懈的努力，化解了种种危机和困境，成为妇孺皆知的女大夫。房成阴谋败露，最终忏悔伏法，谷家父女终于得以团聚。

The son of the famous doctor Gu Feng in Qingyuantang pharmacy was accidentally drowned and Gu Feng’s mother blamed his death on their butler, Fang Cheng. Fang Cheng felt grudged, as his bastard Qiang Wei with his mistress named He Xiu has nowhere to foster her. He secretly substituted his daughter for Gu Feng’s daughter Ren Dong who was once fostered elsewhere. Qiang Wei was brought to Gu family and raised up in a well-off environment, while Ren Dong was raised by He Xiu in a poor family. After they grew up, Ren Dong accidentally got a job in Qingyuantang pharmacy and met with Han Chong, who suffered many hardships in his life. Her optimistic nature and medical talent had soon made her popular in the pharmacy.

어렸을 적 서로 바뀐 운명을 가지고 자라온 주인공이 여러 어려움을 극복하고 마침내 유명한 여의사가 되는 이야기