Season 1 of Bramwell premiered on May 22, 1995.

The series begins in 1895 with Dr. Eleanor Bramwell, working in a London hospital. She is treated as an inferior by the male doctors, and her opinions are often ignored. After a disagreement with a senior doctor, Eleanor is dismissed. Her father, Dr. Robert Bramwell, recommends she join him in his private practice of rich, elderly clients. Fortunately, Eleanor receives a better offer. Lady Peters, a friend of the family, offers to fund a small hospital in a London slum, where Eleanor will treat the impoverished locals. Together, Eleanor and Lady Peters establish The Thrift, a free hospital with six beds. The Thrift is named for its location on Thrift Street.

Season 2 of Bramwell premiered on April 15, 1996.

In the Second Series, The Thrift attempts to survive without Lady Peters' guidance, management and financial assistance. A new character, Dr. Finn O'Neill is introduced when a cholera epidemic occurs in the area and Finn assists in the hospital.

Season 3 of Bramwell premiered on April 21, 1997.

Series Three begins a year after Finn's leaving. He has returned to England for a conference and takes this opportunity to visit Eleanor. Eleanor confirms that she still wishes to be married to Finn in a year when he permanently returns to England. Mr. Marsham considers taking a better position in Edinburgh, but remains at The Thrift.

Season 4 of Bramwell premiered on June 15, 1998.

Eleanor allows The Thrift to perform medical check-ups on soldiers, which leads to her meeting Major Quarrie. Eleanor becomes obsessed with locating the child of a patient at The Thrift and searches the slums.