Sue Thomas is a Deaf woman with the ability to read lips. She moves to Washington, D.C. to begin her new job as an FBI agent and discovers that her new job is not all it's cracked up to be. Due to an out-of-date directory, she accidentally vents her disappointment to Special Agent Jack Hudson, who is impressed by her honesty and tests her skills by having her read a colleague's lips, discovering he is planning a weekend away with a woman. Jack asks Sue to join his Unit of Special Investigators, where she discovers that her new friend Lucy is the girlfriend of Myles, the man Sue saw earlier planning a trip with a different woman.

Sue is put in the uncomfortable position of knowing that her new colleague Myles is having an affair behind his girlfriend Lucy's back while also trying to prove that, now that Jack has given her the chance of a lifetime, she has what it takes to follow through.

When Sue becomes an official member of the team, Jack trains her, and he has a perfect case for her: a bomb threat against a former FBI agent.

While trying to protect an Afghan leader, the team loses their primary assassin. But when they think that all hope is lost, another possible assassin is tracked down and put under surveillance, giving the team interesting results.

After Jack and Bobby arrest a drug dealer they, along with Sue, interrogate him in order to capture other drug dealers in the trade. Meanwhile, the rest of the team is focused on the brand-new offices on the fifth floor.

Having been handed a case about an infamous convict, the team tries to get closer to the convict through his partner, who is deaf.