Season 1 of The Bride of Naga premiered on September 4, 2023.

An epidemic of an unknown disease that gives children in Phanom Nakha strange snake-like scales leads Dr. Benedict to research the phenomenon. Asia, a medical illustrator, is chosen to help him with this. Along the way, the two meet Phumkhaobin, a lively but mysterious man and younger brother to Asia's friend Pheka. When joining the research, Asia couldn't have imagined that she would not only meet mysterious Phumkhaobin but also become involved in the mysterious legend of a village where people worship serpents.