Ameku Takao is a genius doctor with a knack for solving all kinds of difficult cases. When a man with blue blood is brought to Tenikai General Hospital—where Takao is the vice-director—after having his leg bitten off by a large beast, she starts investigating the intriguing case with the aid of her colleague, Takanashi.

Takao's diagnosis seems to solve Enzo's Curse. However, due to a mysterious death by fire, the investigation is right back at square one.