外科女医生齐悦机缘巧合进入平行时空，成为了遇害的侯府少夫人齐月娘，在平行时空的古代世界当，齐悦的到来引起骚动，她不得不在危机四伏的环境下寻找回到现实的办法。而随着秘奉皇命的夫君常云成戍边归来，齐悦举步维艰的生活更是不断面临危机和考验，齐悦以医术之长一一化解危难，为了能回到现实，齐悦凭借医术坐诊谋生，在见识了中医的独特之处与深厚积淀之后，她在中医高手的帮助下学习中医，创新中医的诊疗手段，发扬了传统的中医文化。一场危机后，齐悦和常云成这对有名无实的夫妻不得不同居一室，二人从相看两厌到情愫暗生再到情难自禁，上演大型真香现场，就在两人情投意合之时，却惨遭各方棒打阻碍，齐悦毅然和离而去。其后，二人在京城共历生死危局，探寻身世真相，在边境同浴战火，又经疠疫考验，终于冲破层层阻力，有情人终成眷属。在这场旅程中，齐悦弥合了内心伤痕，不惜以身犯险，到敌国抗击疠疫，终是让她从扬名州府到闻名天下，从一个普通的大夫成长为一代大医。

Modern surgeon Qi Yue is transported to a parallel ancient world, where she becomes the murdered wife of a marquis. Struggling to survive and find a way back, she uses her medical skills to navigate political intrigue and personal challenges. As she learns traditional Chinese medicine and innovates new treatments, she unexpectedly falls for her husband, Chang Yuncheng. Facing betrayals, war, and epidemics, Qi Yue rises from an ordinary doctor to a legendary physician, leaving a lasting legacy.