Mancuso, F.B.I. is a crime drama which was aired by NBC as part of its 1989-90 schedule.

Mancuso, F.B.I. stars veteran actor Robert Loggia as Nick Mancuso, a hardened veteran of the Bureau now assigned to Washington, D.C., where he was largely regarded by his superiors and bureaucratic types as a maverick with little regard for agency rules and procedures. This charge was largely true; Mancuso's true motivation was, as a press release for the show near the time of its premiere described it, "a passionate love affair with the United States Constitution" and an overwhelming desire to see genuine justice rather than the mere appearance of it.

Die Serie basiert auf der Figur des FBI-Agenten Nick Mancuso aus der NBC-Polit-Miniserie Günstling der Hölle, die mit hohen Einschaltquoten ausgestrahlt worden war. Sie wurde am Ende der Staffel abgesetzt.