Gary, Wyatt, and Lisa all decide to go clubbing after hours and become ""creatures of the night."" Lisa turns them all into cool vampires, except the fact that they crave Yoo-Hoo instead of blood. Being vampires gives the guys new powers. They now have the ability to hypnotize people, which they enjoy using on cute women. The night turns out to be not so great when they find themselves with a real group of bloodsucking vampires. Principal Scampi and Chett are determined to stop the vampires and become vampire hunters.

Gary, Wyatt, et Lisa décident de sortir en boîte et deviennent les "stars de la nuit". Lisa les transforme tous en vampires sympas. Les garçons se retrouvent avec des nouveaux pouvoirs, notamment celui de l'hypnose qu'ils vont utiliser pour attirer les filles. Mais une rencontre avec de vrais vampires va changer le cours de la nuit...