Uncle Eddie helps Rich and Seth make a plan to complete Santanico's revenge. Meanwhile, Freddie and Kate encounter an unexpected foe following Malvado's attack.

As the pieces of the big job fall into place, the uneasy trust between brothers and partners crumbles in the light of betrayals and new loyalties.

Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.

Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado’s empire and unleash culebra frenzy on the world.