Season 0 of 1 Litre of Tears premiered on April 5, 2007.

Season 1 of 1 Litre of Tears premiered on October 11, 2005.

The story of a family whose 15-year-old eldest daughter comes down with an incurable disease (Spinocerebellar Degeneration) but puts up a fierce battle to live while bearing up under her infirmity. It also recounts in a positive manner the warm-hearted days of her family, boyfriend, and friends who cried and laughed while supporting her.