Hondo and the S.W.A.T. team race to stop a nuclear attack on Los Angeles when radioactive material is stolen from a local lab.

After an explosive accident at a fruit-packing facility staffed by prison workers, six inmates escape and scatter across the city. Tasked with chasing down the fugitives, Hondo and 20-Squad discover that the worksite explosion was no accident, and that the escapees are working together to carry out a high-stakes robbery. Also, Commander Hicks packs up his office, preparing to vacate the SWAT commander's post, and Gamble gets sobering news about her jailed father.