按摩师矢吹原丈以按摩来破案。他按到的不仅仅是人体的穴位，更是各个案件的“要穴”......

Joe Yabukihara starts working as a masseur with the encouragement of Madam Eco, the owner of a massage shop whom he happened to become acquainted with about a year ago. Recognising that he is gifted in massage, Eco makes Joe go to the homes of all kinds of customers, although it agonizes him because he dislikes people and has anxiety around strangers. One day, the wealthy husband of Joe's customer is murdered and Joe finds himself suspected by police detectives. At the suggestion of fellow masseur Aguri, Joe uses his massage techniques and powers of observation to solve the mystery and clear his name. This becomes the turning point in his life. After that, he keeps getting involved in strange murder cases at customers' homes and demonstrates his unexpected talent each time.

ジョー（中丸雄一）は父親の矢吹原段平（西岡德馬）と再会を果たすが、なぜか段平と一緒に逃走。矢吹原家が代々政府御用達の按摩師だった事とともに、段平が自らの体を酷使するこの仕事を息子に継がせたくない一心で家を出たことを知る。一方『ほぐす堂』では、「病で命が危ない者がいて、今すぐ矢吹原家の人間に診てもらわないと日本が危ない」と大騒ぎになっている。果たしてジョーは無事『ほぐす堂』に戻ってくるのか？それとも…？