Families, friends, enemies and lovers experience life-changing events in the large upstate New York city of Port Charles, which has a busy hospital, upscale hotel, cozy diner and dangerous waterfront frequented by the criminal underworld.

The story of two vampire brothers obsessed with the same girl, who bears a striking resemblance to the beautiful but ruthless vampire they knew and loved in 1864.

A spin-off from The Vampire Diaries and set in New Orleans, The Originals centers on the Mikaelson siblings, otherwise known as the world's original vampires: Klaus, Elijah, and Rebekah. Now Klaus must take down his protégé, Marcel, who is now in charge of New Orleans, in order to re-take his city, as he originally built New Orleans. Klaus departed from the city after being chased down by his father Mikael, while it was being constructed and Marcel took charge. As Klaus has returned after many years, his ego has provoked him to become the king of the city. "Every King needs an heir" says Klaus, accepting the unborn child. The child is a first to be born to a hybrid and a werewolf.

In a place where young witches, vampires, and werewolves are nurtured to be their best selves in spite of their worst impulses, Klaus Mikaelson’s daughter, 17-year-old Hope Mikaelson, Alaric Saltzman’s twins, Lizzie and Josie Saltzman, among others, come of age into heroes and villains at The Salvatore School for the Young and Gifted.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

The story of Stargate SG-1 begins about a year after the events of the feature film, when the United States government learns that an ancient alien device called the Stargate can access a network of such devices on a multitude of planets. SG-1 is an elite Air Force special operations team, one of more than two dozen teams from Earth who explore the galaxy and defend against alien threats such as the Goa'uld, Replicators, and the Ori.