In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters, also referred to as "Cowboys", chase criminals and bring them in alive in return for a reward.

Rick is a mentally-unbalanced but scientifically gifted old man who has recently reconnected with his family. He spends most of his time involving his young grandson Morty in dangerous, outlandish adventures throughout space and alternate universes. Compounded with Morty's already unstable family life, these events cause Morty much distress at home and school.

In the year 2517, after the arrival of humans in a new star system, follow the adventures of the renegade crew of Serenity, a "Firefly-class" spaceship.

A behind-the-scenes look at the people who make a nightly cable-news program. Focusing on a network anchor, his new executive producer, the newsroom staff and their boss, the series tracks their quixotic mission to do the news well in the face of corporate and commercial obstacles-not to mention their own personal entanglements.

A modern update finds the famous sleuth and his doctor partner solving crime in 21st century London.